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Metagenics SPM Active

Please type in the coupon HealthyMe when you check out to get a 10% discount on your Metagenics order.

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Specialized Pro-Resolving Mediators

SPM Active® is designed to help support the body's natural capacity to respond to physical challenges and resolve the immune response.

Both omega-3 fats and SPMs are naturally occurring compounds in our bodies but are commonly low due to low dietary intake and potential issues with their endogenous production. While we have mostly focused on the inflammation-dampening effects of omega-3 fats, it’s important to consider that these actions are carried out by the cells of the immune system. SPM research is rapidly expanding and demonstrating how these compounds influence immune cell behavior. Given the rising concern of infectious diseases, and their effects on those with preexisting inflammatory conditions, we may want to consider omega-3 fats and their SPM derivatives in a new clinical light. by Michael Stanclift, ND (Click here for the full article)

Product Info:

Serving Size:2 SoftGels

Servings Per Container: 60


Amount Per Serving:

  • Calories 10
  • Total Fat 1 g1%
  • Cholesterol, less than5 mg
  • Active Fractionated Marine Lipid Concentrate† SPM content standardized to 18-hydroxy-eicosapentaenoic acid (18-HEPE) and 17-hydroxy-docosahexaenoic acid (17-HDHA) 1 g

Other Ingredients:

Fractionated marine lipid concentrate [ fish oil (anchovy, sardine, and mackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin, water), silica, Contains Fish: anchovy, sardine, mackerel

Dietary Considerations:

  • Gluten Free
  • Non-GMO

Suggested Use:

Take two softgels once daily or as directed by your healthcare practitioner.


Contains: Fish (anchovy, sardine, and mackerel).

This product is non-GMO and gluten free.

Caution: If pregnant, nursing, or taking nutritional supplements or medications, consult your healthcare practitioner before use. Keep out of the reach of children.

Storage: Keep tightly closed in a cool, dry place. Do not use if safety seal is missing or broken.

Available in:

  •   60 softgels
  • 120 softgels
Your Total:

Item Options

Metagenics SPM Active*
Choose your size of SPM Active!
Metagenics SPM Active 60 softgels ($72.00)
Metagenics SPM Active 120 softgels ($122.52)
Dietary Information
Dietary Considerations:
  • Wheat Free
  • Gluten Free
  • Vegetarian
  • Preservative Free
  • Shellfish Free

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